Videos below show αβT-LAK Cells or γδT-LAK Cells, which are activated using MEDINET's state-of-the-art cell engineering technology supported by its intensive cell processing experience, attacking cancer cells to cause apoptosis of the cancer cells.
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0-8 second:
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An αβT-LAK cell finds a Burkitt's Lymphoma cell and adheres the Lymphoma cell.
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9-21 second:
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Then the αβT-LAK cell attacks the Lymphoma cell and infuses various kinds of secreting agents such as Perforin into the Lymphoma cell.
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22-32 second:
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The Lymphoma cell causes apoptosis, so that intracellular substances of the Lymphoma cell such as cytoplasm and nuclear leak out through cell membrance.
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γδT-LAK cells interact Multiple Myeloma cells, and then attack the Myeloma cells; usually T cells attack abnormal cells by infusing various kinds of secreted agents which cause cancer cells apoptosis (programmed cell death inherently.) By this, the Myeloma cells shrink after intracellular materials of the Myeloma cells effuse to cause cell death.
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γδT-LAK Cell:
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Circular cell indicated by blue line in the picture image left.
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Multiple Myeloma Cells:
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Circular cells indicated by red circle in the picture image left.
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This video is taken by collaboration with:
Yousuke Takahama, Ph.D.
Professor, Institute for Genome Research, University of Tokushima |
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γδT-LAK cells' attack makes Breast Cancer cells to remove from the bottom of Petri dish. Then, the cancer cells shrink and form small circular shape, which is typical appearance of cells with early phase of apoptosis. The intracellular materials effuse from the apoptotic cancer cells due to change of osmotic pressure.
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γδT-LAK Cells:
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Smaller circular cells indicated by blue line in the picture image left. |
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Breast Cancer Cells:
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Trapezoidal, oval or larger circular cells indicated by red line in the picture image left.
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This video is taken by collaboration with:
Yousuke Takahama, Ph.D.
Professor, Institute for Genome Research, University of Tokushima |
All rights reserved: Reproduction and/or copy of those videos and images are strictly prohibited.
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